Effect of indole on the mono-oxygenase system in rat liver microsomes.

• WATANUKI Masaaki

  Yakult Central Institute for Microbiological Research

• SAKAI Masashi

  Yakult Central Institute for Microbiological Research

• TOHYAMA Kiyoshi

  Yakult Central Institute for Microbiological Research

• MUTAI Masahiko

  Yakult Central Institute for Microbiological Research

抄録

The effect of indole on the mono-oxygenase systems was studied in liver microsomes from control, indole-, phenobarbital-and 3-methylcholanthrene-treated rats. No induction was observed by indole of either cytochrome P-450 or the mono-oxigenase activities. It was, however, a potent competitive inhibitor of aniline hydroxylase (Ki=0.03mM-0.04mM). A spectroscopic study showed that this competition occurred at the aniline binding site on cytochrome P-450. The inhibitory effect was observed on aminopyrine N-demethylase with less efficiency (Ki=0.1-0.5 mM) and on benzo[a]pyrene hydroxylase. These inhibitions were also observed in the systems of mice, rabbits and monkeys. The physiological effect of indole on liver drug metabolism was also discussed.

収録刊行物

• Agricultural and Biological Chemistry

  Agricultural and Biological Chemistry 46 (1), 215-220, 1982

  公益社団法人 日本農芸化学会

キーワード

• General Agricultural and Biological Sciences
• General Biochemistry, Genetics and Molecular Biology

詳細情報

• CRID: 1390282681440822272
• NII論文ID: 130000028313
• DOI: 10.1271/bbb1961.46.215
• ISSN: 18811280
• ISSN: 00021369
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可