β-Carotene Modulates the Immunological Function of RAW264, a Murine Macrophage Cell Line, by Enhancing the Level of Intracellular Glutathione
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- IMAMURA Tomomi
- Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
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- BANDO Noriko
- Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
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- YAMANISHI Rintaro
- Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
書誌事項
- タイトル別名
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- ベータ Carotene Modulates the Immunological Function of RAW264 a Murine Macrophage Cell Line by Enhancing the Level of Intracellular Glutathione
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抄録
The activities of β-carotene on redox status and the immune functions of RAW264 cells, a murine macrophage cell line, were investigated. Supplementation with β-carotene for RAW264 cells resulted in apparently inconsistent redox indices: lipid peroxidation was enhanced but intracellular oxidation was moderately attenuated. Attenuated intracellular oxidation was endorsed by an increase in glutathione accompanied by up-regulated transcription of a subunit of γ-glutamylcysteine synthetase, the rate-limiting enzyme for glutathione synthesis. α-Tocopherol, which can quench lipid peroxidation by free radical, neither inhibited that by β-carotene nor influenced the intracellular redox status. Lipopolysaccharide-stimulated transcriptions of IL-1β and IL-12 p40 in RAW264 were inhibited by β-carotene but not by α-tocopherol. These results indicate that β-carotene, which can modulate the intracellular redox status of macrophages by enhancing the level of intracellular glutathione, is related to the immune functions of macrophages.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (9), 2112-2120, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681457311872
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- NII論文ID
- 130000029728
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD28XhtFSjtbfM
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8073410
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可