A Phytochemical in the Edible Tamogi-take Mushroom (Pleurotus cornucopiae), D-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

  • HAGIWARA Shin-ya
    Three B Co., Inc. Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
  • TAKAHASHI Masayuki
    Bioorganic Chemistry, Division of Chemistry, Graduate School of Science, Hokkaido University
  • SHEN Yanbo
    Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
  • KAIHOU Shinobu
    Three B Co., Inc.
  • TOMIYAMA Takahiro
    Three B Co., Inc.
  • YAZAWA Michio
    Bioorganic Chemistry, Division of Chemistry, Graduate School of Science, Hokkaido University
  • TAMAI Yutaka
    Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
  • SIN Yoosu
    Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University
  • KAZUSAKA Akio
    Advanced Technology Co., Ltd.
  • TERAZAWA Minoru
    Research Group for Forest Resource Science, Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University

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  • Phytochemical in the Edible Tamogi take Mushroom Pleurotus cornucopiae D Mannitol Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats
  • A Phytochemical in the Edible Tamogi-take Mushroom (<i>Pleurotus cornucopiae</i>),<scp>D</scp>-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

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Abstract

D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.

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