Myricitrin Degraded by Simulated Digestion Inhibits Oxidation of Human Low-Density Lipoprotein

• YOKOMIZO Atsushi

  Fundamental Research Division, San-Ei Gen F.F.I. Corporation

• MORIWAKI Masamitsu

  Fundamental Research Division, San-Ei Gen F.F.I. Corporation

抄録

The inhibitory effects of myricitrin on the oxidation of human low-density lipoprotein were investigated before and after its degradation by simulated digestion. Myricitrin strongly inhibited the low-density lipoprotein oxidation induced by either 2,2′-azobis (2-amidinopropane) dihydrochloride or CuSO₄ in a concentration-dependent manner. Myricitrin was very stable under an acidic condition (pH 1.8) corresponding to the gastric environment, but it was easily degraded under an alkaline condition (pH 8.5) corresponding to the intestinal environment. However, degraded myricitrin also had a strong inhibitory effect on the oxidative degradation of α-tocopherol, cholesterol and apolipoprotein B-100 in low-density lipoprotein. Our study revealed that myricitrin was degraded into many components under a mildly alkaline condition, but the degraded myricitrin still retained the free radical-scavenging and copper-chelating activities toward low-density lipoprotein.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 69 (4), 693-699, 2005

  公益社団法人 日本農芸化学会

キーワード

• myricitrin
• flavonoid
• low-density lipoprotein
• oxidation
• atherosclerosis

詳細情報

• CRID: 1390001206475277824
• NII論文ID: 130000030349
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.69.693
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 7308262
• PubMed: 15849406
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7308262
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.69.693
• Web Site: https://search.jamas.or.jp/link/ui/2006247636
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可