Lifespan Extending Activity of Substances Secreted by the Nematode<i>Caenorhabditis elegans</i>That Include the Dauer-Inducing Pheromone

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  • KAWANO Tsuyoshi
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • KATAOKA Naoya
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • ABE Sunao
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • OHTANI Mari
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
  • HONDA Yoko
    Tokyo Metropolitan Institute of Gerontology
  • HONDA Shuji
    Tokyo Metropolitan Institute of Gerontology
  • KIMURA Yasuo
    Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University

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  • Lifespan Extending Activity of Substances Secreted by the Nematode Caenorhabditis elegans That Include the Dauer-Inducing Pheromone

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The nematode Caenorhabditis elegans yields a substance(s) inducing the larval diapause, called dauer-inducing pheromone. We discovered that the crude pheromone extract extends the adult lifespan in the animal. This extension does not occur in the mutant animal, in which expansion of the lifespan caused by other mutations reducing insulin signaling is suppressed. This is the first description concerning the relevancy of the pheromone to the longevity in the animal.

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