Stimulation of IL-8 Production by<i>Aralia cordate</i>Lectin in Human Colon Carcinoma Caco-2 Cells
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- KOYAMA Yu
- School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of Shizuoka
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- SUZUKI Takuji
- School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of Shizuoka
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- KAJIYA Akane
- School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of Shizuoka
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- ISEMURA Mamoru
- School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of Shizuoka
書誌事項
- タイトル別名
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- Stimulation of IL-8 Production by Aralia cordate Lectin in Human Colon Carcinoma Caco-2 Cells
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抄録
Some lectins are known to stimulate interleukin-8 (IL-8) productions in human colon carcinoma Caco-2 cells. Since IL-8 may cause deleterious effects, we examined this stimulatory activity of Aralia cordate lectin (ACL) and Wasabia japonica lectin (WJL), both of which we isolated recently. The results indicate that ACL exhibited strong stimulatory activity for IL-8 protein production, while WJL showed marginal activity. The activity of ACL was associated with high enhancement of IL-8 gene expression. The effect of ACL was abolished almost completely in the presence of brefeldin A, indicating that internalization into cells is necessary for ACL to exert activity. The findings suggest that ingestion of a large amount of raw vegetable Aralia cordate might cause unfavorable effects on the colon.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (1), 202-205, 2005
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681453237376
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- NII論文ID
- 130000030572
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7237487
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- PubMed
- 15665486
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可