Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines

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  • KAWAHARA Takeshi
    Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
  • KATAYAMA Daisuke
    Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
  • OTANI Hajime
    Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University

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タイトル別名
  • Effect of .BETA.-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
  • Effect of ベータ Casein 1 28 on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines

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The effect of bovine β-casein (1-28) purified from commercial casein phosphopeptide preparations on human T, B, and monocyte cell lines was evaluated. Beta-casein (1-28) enhanced the proliferation of the following: T cell lines HUT-78, Jurkat Clone E6-1, and MOLT-4; B cell lines BALL, KHM-1B, and U266B1; and monocyte cell lines U937 and HL-60. Moreover, β-casein (1-28) stimulated IgA production by KHM-1B over 96 h of culture. Semiquantitative reverse transcriptional-polymerase chain reaction analysis indicated that β-casein (1-28) enhanced mRNA expression of interleukin (IL)-6 in U266B1 and KHM-1B. These results suggest that β-casein (1-28) exerts a mitogenic effect on human T, B, and monocyte cells, and an IgA-enhancing effect on B cells.

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