季節性アレルギー性鼻炎有症者を対象とした「べにふうき」緑茶の抗アレルギー作用評価とショウガによる増強効果 Effects and Safety of Consecutive Intake of Benifuuki Green Tea and Enhancement of the Effect by Ginger Extract in Subjects with Japanese Cedar-pollinosis

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著者

    • 永井 寛 NAGAI Hiroshi
    • アサヒ飲料(株)飲料研究所 Beverage Research&Development Laboratory, Asahi Soft Drinks Co., Ltd
    • 江間 かおり [他] EMA Kaori
    • 独立行政法人 農業・生物系特定産業技術研究機構 野菜茶業研究所 National Institute of Vegetable and Tea Science
    • 神田 えみ KANDA Emi
    • 独立行政法人 農業・生物系特定産業技術研究機構 野菜茶業研究所 National Institute of Vegetable and Tea Science
    • 岡田 典久 OKADA Norihisa
    • 独立行政法人 農業・生物系特定産業技術研究機構 野菜茶業研究所 National Institute of Vegetable and Tea Science

抄録

A double-blind clinical study was carried out on subjects with Japanese cedar pollinosis for the evaluation of the effects and safety of 'Benifuuki' green tea, which contains epigallocatechin-3-<i>O</i>-(3-<i>O</i>-methyl)-gallate (<i>O</i>-methylated catechin), and a combination of 'Benifuuki' green tea and ginger extract, with 'Yabukita' green tea as a placebo. First, the effect of the combination of 'Benifuuki' green tea and various vegetable extracts on cytokine production inhibition was investigated using mast cells ; the simultaneous use of 'Benifuuki' green tea and ginger extract was found to suppress cytokine (TNF-α or MIPI-α) production to a remarkable extent. Subjects were given 1.5 g of 'Benifuuki' green tea, 'Benifuuki' green tea containing 30 mg of ginger extract, or 'Yabukita' green tea with water twice every day for 13 weeks. As cedar pollen scattering increased, the severity of pollinosis symptoms among the groups was observed to increase in the following order : placebo group>'Benifuuki' group>'Benifuuki' and ginger group. Eleven weeks after the beginning of treatment, during the most severe cedar pollen scattering period, symptoms of runny nose and itchy eyes were significantly relieved among the 'Benifuuki' group compared with the placebo group (<i>p</i><0.05). In the 'Benifuuki' and ginger group, runny nose, itchy eyes and nose symptom scores were significantly reduced at the eleventh week, and nasal congestion, sore throat and nose symptom medication scores were significantly reduced at the thirteenth week compared with the placebo group. Among all test groups, hematological examination, general biochemical examination, determination of total IgG, CMV antibody titer, and serum iron content, and interviews throughout the intake period found no changes related to clinical problems. These results suggest that intake of 'Benifuuki' green tea over one month is useful in reducing some of the symptoms of Japanese cedar pollinosis, and did not affect normal immune response in subjects with Japanese cedar-pollinosis. It was also found that the addition of ginger extract enhanced the effect of 'Benifuuki' green tea.

収録刊行物

  • 日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology

    日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology 52(12), 584-593, 2005-12-15

    Japanese Society for Food Science and Technology

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各種コード

  • NII論文ID(NAID)
    130000052744
  • NII書誌ID(NCID)
    AN10467499
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    1341027X
  • NDL 記事登録ID
    7740873
  • NDL 雑誌分類
    ZP34(科学技術--食品工学・工業)
  • NDL 請求記号
    Z17-126
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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