A Case of Periodic Spasms which Disappeared after Corpus Callosotomy

DOI 6 References
  • Kimura Seiji
    Division of Pediatrics and Pediatric Neurology, Yokohama Ryoiku-Medical Center
  • Saito Yoshiaki
    Division of Pediatrics and Pediatric Neurology, Yokohama Ryoiku-Medical Center
  • Tanabe Yutaka
    Department of Neurosurgery, Yokohama City University

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  • 脳梁離断術後に発作が消失したＰｅｒｉｏｄｉｃ　Ｓｐａｓｍｓの１例

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Abstract

Periodic spasms (PS) is an epileptic seizure type exhibits West syndrome-like series-forming spasms. Ictal EEG consists of generalized high voltage slow waves preceded by fast waves. This type of discharge is often misinterpreted as a non-epileptic discharge, because it lacks spike or sharp wave. Observation on the ictal symptoms or a video-EEG is necessary to confirm PS. PS is usually resistant to antiepileptic drugs. The present patient first experienced PS at the age of 18 months. Complex partial seizures, sporadic tonic spasms and drop attacks emerged and increased in frequency in spite of polypharmacy. At age 15 he was subjected to a total corpus callosotomy because of the increased incidence of traumas due to drop attacks. During two years of follow-up after callosotomy, all types of seizures have never been recurred. The reason why the callosotomy was effective in this case was not clear. However, it suggests that the role of the corpus callosum is not only a pathway of epileptic discharges but affects on the bilateral synchrony of multifocal epileptic discharges.<br>

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