Folate Deficiency Results in Alteration in Intestinal Brush Border Membrane Composition and Enzyme Activities in Weanling Rats
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- SINGLA Amika
- Department of Biochemistry, Post Graduate Institute of Medical Education and Research
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- KAUSHIK Susmita
- Department of Biochemistry, Post Graduate Institute of Medical Education and Research
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- KAUR Jyotdeep
- Department of Biochemistry, Post Graduate Institute of Medical Education and Research
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Folic acid deficiency is the most prevalent vitamin deficiency throughout the world and its effect on brush border membrane composition has not been studied earlier. We investigated the effect of folate deficiency on the structure and function of the intestinal brush border membrane. Various brush border enzyme activities, membrane sugars and lipids were evaluated in two groups of weanling male albino rats after 3 mo of feeding control and folate deficient diets. Except sucrase, all the other three enzymes, viz., alkaline phosphatase, leucine amino peptidase and γ-glutamyl transpeptidase showed decrease in activity in rats fed folate-deficient diets. Among sugars, hexoses and hexosamines showed significant decline in amount whereas sialic acid content showed great increase in brush border membrane of folate-deficient rats as compared to controls. Furthermore, there was a significant reduction in cholesterol, phospholipids, triglycerides, cerebrosides and fucolipids in the group fed the folate-deficient diet. Our study suggests that folate deficiency results in altered enzyme activities, lipid and sugar composition of intestinal brush border membrane. Such changes might reflect the underlying cause of the gastrointestinal disturbances observed in folate deficiency.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 52 (3), 163-167, 2006
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詳細情報 詳細情報について
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- CRID
- 1390282681301451520
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- NII論文ID
- 130000058220
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD28XntFehsLs%3D
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 7965002
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可