5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses

DOI Web Site 被引用文献5件 参考文献10件
  • Lu Dong-ping
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo Mitsubishi Kagaku Bio-Clinical Laboratories, Inc.
  • Nakayama Hiroyuki
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
  • Shinozuka Junko
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
  • Uetsuka Koji
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
  • Taki Ryuichi
    Mitsubishi Kagaku Bio-Clinical Laboratories, Inc.
  • Doi Kunio
    Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo

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Pregnant Wistar rats were injected i.p. with 5-azacytidine (5AzC) at 11 day of gestation. Brain cell apoptosis determined morphologically or by TUNEL method was observed in the fetuses 3 hrs after injection. Eight to 100% of the fetuses were dead at 1 to7 day after injection. Injection with doses less than 5 mg/kg of 5AzC killed only a few fetuses, though neuronal apoptosis was detected in most of living fetuses. All fetuses were dead when their dams were injected with 5AzC at 9 or 10 day of gestation, whereas most of the fetuses were alive when injected after day 12. The present study revealed that 5AzC specifically induce neuronal apoptosis in rat fetuses at the stage of logarithmic growth.

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