Roles of μ-opioid receptors in development of tolerance to diisopropylfluorophosphate (DFP)
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- TIEN Lu-Tai
- Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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- FAN Lir-Wan
- Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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- MA Tangeng
- Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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- LOH Horace H.
- Department of Pharmacology, University of Minnesota Medical School
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- HO Ing Kang
- Department of Pharmacology and Toxicology, University of Mississippi Medical Center
書誌事項
- タイトル別名
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- ROLES OF .MU.-OPIOID RECEPTORS IN DEVELOPMENT OF TOLERANCE TO DIISOPROPYLFLUOROPHOSPHATE (DFP)
- Roles of ミュー opioid receptors in development of tolerance to diisopropylfluorophosphate DFP
この論文をさがす
抄録
- Anatomical evidence indicates that cholinergic and opioidergic systems are co-localized and acting on the same neuron. However, the regulatory mechanisms between cholinergic and opioidergic system have not been well characterized. In the present study, the potential involvement of μ-opioid receptors in mediating the changes of toxic signs and muscarinic receptor binding after administration of irreversible anti-acetylcholinesterase diisopropylfluorophosphate (DFP) was investigated. DFP (1 mg/kg/day, subcutaneous injection, s.c.)-induced tremors and chewing movements were monitored during the 28-day treatment period in μ-opioid receptor knockout and wild type mice. Autoradiographic studies of total, M1, and M2 muscarinic receptors were conducted using [3H]-quinuclidinyl benzilate, [3H]-pirenzepine, and [3H]-AF-DX384 as ligands, respectively. DFP-induced tremors in both μ-opioid receptor knockout and wild type mice showed tolerance development. However, DFP-induced tremors in μ-opioid receptor knockout mice showed delayed tolerance development than that of DFP-treated wild type controls. DFP-induced chewing movements in both μ-opioid receptor knockout and wild type mice failed to show development of tolerance after four weeks of treatment. M2 muscarinic receptor binding of DFP-treated μ-opioid receptor knockout mice was significantly decreased than that of the DFP-treated wild type controls in the striatum, but not in the cortex and hippocampus. However, there were no significant differences in total and M1 muscarinic receptor binding between DFP-treated μ-opioid receptor knockout and wild type mice in the cortex, striatum and hippocampus. These studies indicate that μ-opioid receptors play an important role through the striatal M2 muscarinic receptors to regulate the development of tolerance to DFP-induced tremors.<br>
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 30 (1), 43-59, 2005
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679878151296
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- NII論文ID
- 130000065384
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 7262943
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- PubMed
- 15800401
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可