The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive Bronchial-Hypersensitive(BHR) Guinea Pigs

• YAGI Yukihiro

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• KUWAHARA Masayoshi

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• NANJI Atsumi

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• BIRUMACHI Jun-ichi

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

• NISHIBATA Ryoji

  Institute of Bio-Active Science, Nippon Zoki Pharmaceutical

• MIKAMI Hiroki

  Institute of Bio-Active Science, Nippon Zoki Pharmaceutical

• TSUBONE Hirokazu

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

書誌事項

タイトル別名

• The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.
• Difference in Citric Acid Induced Cough in Congenitally Bronchial Hypersensitive Bronchial Hypersensitive BHR Guinea Pigs

抄録

Cough elicitation and major physiological factors influencing cough occurrence were investigated in congenitally bronchial-hypersensitive (BHS) and -hyposensitive (BHR) guinea pigs exposed to citric acid (0.3 M) aerosol for 10 min. The number of cough in BHS was significantly larger than in BHR, while the latency to cough in BHS was significantly shorter than in BHR. Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR. The salbutamol, atropine and capsaicin pretreatments prolonged the cough latency in BHS, but only salbutamol prolonged the latency in BHR. After salbutamol pretreatment all BHR guinea pigs exhibited cough, while 66.7% of BHS guinea pigs exhibited it. Vagal blocking by atropine suppressed coughing in both BHS and BHR. Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment. The present study demonstrated that the cough responsiveness to citric acid aerosol was significantly higher in BHS than in BHR. It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 50 (5), 371-378, 2001

  公益社団法人 日本実験動物学会

キーワード

• airway
• C-fiber
• cough
• guinea pig

詳細情報

• CRID: 1390001205041859968
• NII論文ID: 130000068673
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.50.371
• COI: 1:CAS:528:DC%2BD38Xhs1OlsQ%3D%3D
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 5945973
• PubMed: 11769539
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5945973
• Web Site: http://www.jstage.jst.go.jp/article/expanim/50/5/50_5_371/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002121775
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可