The Effects of Walking Exercise Training on Immune Response in Elderly Subjects

DOI 被引用文献4件 参考文献12件
  • Kimura Fuminori
    Department of Comprehensive Human Sciences, Tsukuba University
  • Shimizu Kazuhiro
    Department of Comprehensive Human Sciences, Tsukuba University
  • Akama Takao
    Faculty of Sport Sciences, Waseda University
  • Akimoto Takayuki
    Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical care, Waseda University
  • Kuno Shinya
    Department of Comprehensive Human Sciences, Tsukuba University
  • Kono Ichiro
    Department of Comprehensive Human Sciences, Tsukuba University

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The immune function declines in efficiency with advancing age, making the elderly less resistant to pathogenic microorganisms. The effects of walking exercise training (five 30-min walking sessions/week at 80% VT) on salivary secretory IgA (SIgA) and plasma lymphocyte subpopulations were studied in elderly subjects. Thirty sedentary, elderly subjects (8 men, 22 women; age 66.7±7.4 years) performed walking exercise for 3 months. Aerobic power, body composition, and immune function were examined before (Pre) and after training (3 months). Salivary SIgA flow rate were measured by enzyme linked immunosorbent assay (ELISA), while lymphocyte subpopulations were measured by flow cytometry. SIgA flow rate significantly increased at 3 months, especially in 64-year-olds and under (U-64), 65∼85-year-olds (65-85), and female elderly subjects. Number of total lymphocytes, NK cell, and memory-Th cell significantly decreased at 3 months. We conclude that 3 months of walking provides enhancement of mucosal immune function in elderly subjects, although it is not associated with an improvement in lymphocytes.

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