A Novel A-Kinase Anchoring Protein in the Heart Interacts with G .ALPHA. 13.
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- SUZUKI Miwako
- Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- FURUUCHI Keiji
- Division of Cell Biology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
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- TONOKI Hidefumi
- Division of Cell Biology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
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- OZAKI Takefumi
- Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- IIZUKA Kenji
- Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- MURAKAMI Takeshi
- Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- KITABATAKE Akira
- Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- KAWAGUCHI Hideaki
- Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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抄録
A cDNA of a tentative A-kinase anchoring protein, presumably coupled with heterotrimeric GTP binding protein α 13 subunit (G α 13), was cloned from a human heart cDNA library. It was approximately 650 bases and its mRNA was expressed in the heart. Homology search of DNA sequences revealed that it was a novel cDNA with 84% homology with the partial sequence of rabbit cDNA of AKAP 120 without a stop codon. 3'-Rapid Amplification of cDNA Ends (3'-RACE) and yeast functional assay were performed to determine the 3'-end of the cDNA and ribosomal frameshifting was suggested as a translational mechanism. Here we report that a protein encoded by the cDNA may be involved in intracellular signal transduction via the G α 13 and PKA in hearts.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 40 (2), 199-208, 1999
International Heart Journal刊行会