Oral plexiform neurofibroma not associated with neurofibromatosis type I: case report

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  • Marocchio Luciana S.
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo
  • Pereira Michele C.
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo
  • Soares Cléverson T.
    Department of Pathology, Lauro de Souza Lima Research Institute
  • Oliveira Denise T.
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo

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Abstract

An unusual case of isolated plexiform neurofibroma arising in the oral cavity without other clinical manifestations or family history of neuro-fibromatosis-1 (NF-1) is described. The tumor was histopathologically analyzed and an immunohisto-chemical panel comprising S-100 protein, epithelial membrane antigen (EMA), collagen IV, and CD34 was performed. Typical features of plexiform neurofibroma characterized by enlarged nerve fascicles composed of elongated nuclei and scant cytoplasm cells were identified. Subjacent to the oral epithelium, tactile-like bodies were also detected. On the basis of this report, we would like to emphasize that plexiform neurofibroma can occur in the oral cavity as a benign isolated tumor in patients without other stigmata of NF-1. (J. Oral Sci. 48, 157-160, 2006)

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