Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils
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- Shimoyama Tadashi
- First Department of Internal Medicine, Hirosaki University School of Medicine
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- Fukuda Shinsaku
- First Department of Internal Medicine, Hirosaki University School of Medicine
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- Liu Qiang
- Department of Hygiene, Hirosaki University School of Medicine
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- Fukuda Yoshihiro
- Department of Gastroenterology, Hyogo Medical College
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- Nakaji Shigeyuki
- Department of Hygiene, Hirosaki University School of Medicine
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- Sugawara Kazuo
- Department of Hygiene, Hirosaki University School of Medicine
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The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimulated with opsonized zymosan, 12-myristate 13-acetate phorbol, and calcium ionophore in a dose-dependent manner, but the LgCL response was inhibited when neutrophils were stimulated with opsonized zymosan. LmCL response was also dose-dependently attenuated by rebamipide even in the presence of cimetidine. Thus, addition of rebamipide to H2-receptor antagonists can be considered for the treatment of gastric mucosal injury associated with oxidative stress.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 91 (2), 153-157, 2003
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680153620736
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- NII論文ID
- 130000073718
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BD3sXhslCkt7c%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 6581901
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- PubMed
- 12686760
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
