Lysophosphatidic Acid Enhances In Vivo Infiltration and Activation of Guinea Pig Eosinophils and Neutrophils via a Rho/Rho-Associated Protein Kinase-Mediated Pathway.

DOI Web Site PubMed 被引用文献3件 参考文献37件
  • Hashimoto Terumasa
    Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
  • Yamashita Miyuki
    Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
  • Ohata Hisayuki
    Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
  • Momose Kazutaka
    Department of Pharmacology, School of Pharmaceutical Sciences, Showa University

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Lysophosphatidic acid (LPA) has been shown to be a chemoattractant in in vitro studies. The present study was carried out to determine whether LPA enhances infiltration of inflammatory cells in in vivo studies with guinea pigs. LPA (1 – 10 μg/ml), when by guinea pigs for 5 min, substantially increased the numbers of eosinophils and neutrophils in the bronchoalveolar lavege fluid (BALF), which was recovered at over 4 h after the inhalation of LPA. Infiltration in BALF was significantly inhibited by inhalation of Y-27632, an inhibitor of Rho-associated protein kinase (ROCK). LPA also increased superoxide production of eosinophils and neutrophils. In contrast, Y-27632 inhibited superoxide production. These findings suggest that LPA may contribute to infiltration and activation of inflammatory cells in bronchial asthma; furthermore, the Rho/ROCK-mediated pathway may be involved.<br>

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