Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
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- Chiba Yoshihiko
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- Uchida Tetsuro
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- Sakai Hiroyasu
- Department of Pharmacology, School of Pharmacy, Hoshi University
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- Oku Teruaki
- Department of Microbiology, School of Pharmacy, Hoshi University
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- Itoh Saotomo
- Department of Microbiology, School of Pharmacy, Hoshi University
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- Tsuji Tsutomu
- Department of Microbiology, School of Pharmacy, Hoshi University
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- Misawa Miwa
- Department of Pharmacology, School of Pharmacy, Hoshi University
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By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in the cytosolic space with no staining in the nucleus, whereas acetylcholine stimulation induced a relocalization of RhoA to the cell periphery. From the results of line scans and surface plots, the peripheral to cytosolic ratio of RhoA was significantly increased by acetylcholine stimulation. Thus, the present study clearly demonstrated an acetylcholine-induced translocation of RhoA to the plasma membrane in single bronchial smooth muscle cells of the rat.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 95 (4), 479-482, 2004
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680151986048
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- NII論文ID
- 10014165998
- 130000074353
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7049721
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- PubMed
- 15297770
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可