Aspirin may exert its antipyresis by inhibiting the N-methyl-D-aspartate receptor-dependent hydroxyl radical pathways in the hypothalamus

• Kao Ting-Yu

  Institute of Physiology, National Yang-Ming University School of Medicine, Taiwan Department of Medical Technology, YuanPei University, Taiwan

• Huang Wu-Tein

  Department of Health Care Administration, Diwan College of Management, Taiwan

• Chang Ching-Ping

  Department of Biotechnology, Southern Taiwan University of Technology, Taiwan

• Lin Mao-Tsun

  Department of Medical Research, Chi Mei Medical Center, Taiwan

書誌事項

タイトル別名

• Aspirin May Exert Its Antipyresis by Inhibiting the N-Methyl-<sc>D</sc>-aspartate Receptor-Dependent Hydroxyl Radical Pathways in the Hypothalamus

抄録

Recent findings have suggested that the N-methyl-<sc>D</sc>-aspartate (NMDA) receptor-dependent hydroxyl radical pathway in the hypothalamus of rabbit brain may mediate the fever induced by lipopolysaccharide (LPS). The aim of this study was to investigate whether aspirin exerts its antipyresis by suppressing hypothalamic glutamate and hydroxyl radicals in rabbits. The microdialysis probes were stereotaxically and chronically implanted into the preoptic anterior hypothalamus of rabbit brain for determination of both glutamate and hydroxyl radicals in situ. It was found that intravenous (i.v.) injection of LPS, in addition to inducing fever, caused increased levels of both glutamate and hydroxyl radicals in the hypothalamus. Pretreatment with aspirin (10 – 60 mg/kg, i.v.) one hour before an i.v. dose of LPS significantly reduced the febrile response and attenuated the LPS-induced increased levels of both glutamate and hydroxyl radicals in the hypothalamus. The increased levels of prostaglandin E₂ (PGE₂) in the hypothalamus induced by LPS could be suppressed by aspirin pretreatment. The data indicate that systemic administration of aspirin, in addition to suppressing PGE₂ production, may exert its antipyresis by inhibiting the NMDA receptor-dependent hydroxyl radical pathways in the hypothalamus during LPS fever.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 103 (3), 293-298, 2007

  公益社団法人 日本薬理学会

キーワード

• fever
• lipopolysaccharide
• glutamate
• hydroxyl radical
• aspirin

詳細情報

• CRID: 1390282680153715968
• NII論文ID: 10024313019
• NII論文ID: 130000075045
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fp0061460
• COI: 1:STN:280:DC%2BD2s7ntF2msQ%3D%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 8690362
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8690362
• Web Site: https://search.jamas.or.jp/link/ui/2007235357
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可