Markedly Improved Glycemic Control and Enhanced Insulin Sensitivity in a Patient with Type 2 Diabetes Complicated by a Suprasellar Tumor Treated with Pioglitazone and Metformin

• IGAKI Naoya

  Department of Internal Medicine, Takasago Municipal Hospital

• TANAKA Maki

  Department of Internal Medicine, Takasago Municipal Hospital

• GOTO Takeo

  Department of Internal Medicine, Takasago Municipal Hospital

抄録

A patient with type 2 diabetes and hypothalamic damage due to a suprasellar tumor developed impaired glycemic control and central obesity. The patient showed exaggerated adrenocorticotropic hormone responsiveness as determined by a corticotrophin releasing hormone test and elevated serum leptin concentrations associated with ravenous appetite and insulin resistance mediated in part through disturbances in leptin signaling. Combination treatment with metformin and pioglitazone was markedly effective in improving glycemic control. Additionally, metformin treatment showed marked anorectic effects on the hyperphagia. This case has important implications for the pathogenesis and management of diabetes in patients with hypothalamic-pituitary-adrenal axis deficiencies.

収録刊行物

• Internal Medicine

  Internal Medicine 44 (8), 832-837, 2005

  一般社団法人 日本内科学会

キーワード

• leptin
• insulin resistance
• hypothalamic-pituitary-adrenal axis
• central obesity

詳細情報

• CRID: 1390282679846172800
• NII論文ID: 130000076345
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.44.832
• ISSN: 13497235
• ISSN: 09182918
• NDL書誌ID: 7402181
• PubMed: 16157982
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7402181
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/44/8/44_8_832/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006293450
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可