Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Vasodilation in Rat Aorta.

• Yamaguchi Kiyoshi

  Department of Pharmacology, Tokyo University of Pharmacy and Life Science

• Honda Hideo

  Department of Pharmacology, Tokyo University of Pharmacy and Life Science

• Wakisaka Chiaki

  Department of Pharmacology, Tokyo University of Pharmacy and Life Science

• Tohei Atsushi

  Department of Pharmacology, Tokyo University of Pharmacy and Life Science

• Kogo Hiroshi

  Department of Pharmacology, Tokyo University of Pharmacy and Life Science

抄録

The influence of the phytoestrogen, isoflavones, on vasodilating responses of the thoracic aorta precontracted with norepinephrine, together with the stimulatory effect on uterine weight (uterotrophic effect), was investigated in ovariectomized rats. In comparison with intact rats, acetylcholine (ACh)-induced vasodilation showed a tendency to be decreased by ovariectomy. On the other hand, isoprenaline (ISO)-induced vasodilation was significantly increased by ovariectomy. Estrogen replacement (17β-estradiol dipropionate, 300 μg/kg per week, for 1 month) completely restored the impaired ACh- and ISO-induced vasodilation caused by ovariectomy. Dietary isoflavone aglycones (containing 52% genistein, 42% daidzein and 6% glycitein) of 157 mg/kg per day (not 67 mg/kg per day) for 1 month, in addition to the effects of estrogen replacement, completely restored the impaired vasodilation caused by ovariectomy. However, the uterotrophic effect of dietary isoflavones of 157 mg/kg per day was incomplete as compared with that by estrogen replacement. These results indicate that phytoestrogen, isoflavones, certainly possess estrogenic actions on the vasodilating responses caused by ACh and ISO, as well as a weaker uterotrophic effect.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 87 (1), 67-73, 2001

  公益社団法人 日本薬理学会

キーワード

• Isoflavones (genistein and daidzein)
• Estradiol
• Acetylcholine
• Isoprenaline
• Rat aorta

詳細情報

• CRID: 1390282679262048640
• NII論文ID: 130000078341
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.87.67
• COI: 1:CAS:528:DC%2BD3MXntFWks74%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5919047
• PubMed: 11676200
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5919047
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819303105?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819303105?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2002110162
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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