Recent Advances in the Search for the N-Opioidergic System: Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System
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- Wang Qing-Ping
- Department of Anatomy, Showa University School of Medicine
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- Zadina James E.
- Department of Veterans Affairs Medical Center Department of Medicine, Tulane University School of Medicine Neuroscience Program, Tulane University School of Medicine
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- Guan Jian-Lian
- Department of Anatomy, Showa University School of Medicine
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- Shioda Seiji
- Department of Anatomy, Showa University School of Medicine Department of Medicine, Tulane University School of Medicine
書誌事項
- タイトル別名
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- Recent Advances in the Search for the .MU.-Opioidergic System. Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System.
- Recent advances in the search for the μ-opioidergic system: morphological studies of the endomorphinergic neurons in the central nervous system
- Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System
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抄録
Endomorphins (EMs) are newly found endogenous opioid peptides. Both endomorphin-1 (EM-1) and -2 (EM-2) are composed of four amino acids. Their high affinity and specificity for μ-opioid receptors have been confirmed by many physiological and pharmacological studies. In the present minireview, we discuss the distribution and localization of these peptides. While EM-2 is more prevalent in the spinal cord and lower brainstem, EM-1 is more widely and densely distributed throughout the brain than EM-2. We also discuss the possible coexistence of EM with other neurotransmitters. Finally, we introduce some new results regarding the ultrastructure and synaptic relationships of EM-2 obtained by the immunoelectron microscopic method.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 89 (3), 209-215, 2002
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204285930624
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- NII論文ID
- 130000078472
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- NII書誌ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD38vivVWlug%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 6236196
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- PubMed
- 12184723
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可