IgG4-related Autoimmune Prostatitis: Two Cases with or without Autoimmune Pancreatitis

• Nishimori Isao

  Department of Gastroenterology and Hepatology, Kochi Medical School

• Kohsaki Takuhiro

  Department of Gastroenterology and Hepatology, Kochi Medical School

• Onishi Saburo

  Department of Gastroenterology and Hepatology, Kochi Medical School

• Shuin Taro

  Department of Urology, Kochi Medical School

• Kohsaki Shino

  Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School

• Ogawa Yasuhiro

  Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School

• Matsumoto Manabu

  Laboratory of Diagnostic Pathology, Kochi Medical School

• Hiroi Makoto

  Laboratory of Diagnostic Pathology, Kochi Medical School

• Hamano Hideaki

  Department of Medicine, Gastroenterology, Shinshu University School of Medicine

• Kawa Shigeyuki

  Center for Health, Safety and Environmental Management, Shinshu University

Abstract

Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [¹⁸F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.<br>

Journal

• Internal Medicine

  Internal Medicine 46 (24), 1983-1990, 2007

  The Japanese Society of Internal Medicine

Keywords

• autoimmune pancreatitis
• prostatitis
• IgG4-related sclerosing disease
• positron emission tomography with [¹⁸F] fluorodeoxyglucose
• steroid therapy

Details

• CRID: 1390282679848138752
• NII Article ID: 130000078591
• NII Book ID: AA10827774
• DOI: 10.2169/internalmedicine.46.0452
• COI: 1:STN:280:DC%2BD2sjks1KmsQ%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• PubMed: 18084121
• Web Site: http://hdl.handle.net/10126/3103
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/46/24/46_24_1983/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008214837
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed