Relapsing Campylobacter Coli Bacteremia with Reactive Arthritis in a Patient with X-linked Agammaglobulinemia
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- Arai Ayako
- Department of Hematology, Tokyo Madical and Dental University
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- Kitano Asako
- Department of Hematology, Tokyo Madical and Dental University
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- Sawabe Etsuko
- Department of Clinical Laboratory, Tokyo Madical and Dental University
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- Kanegane Hirokazu
- Department of Pediatrics, Faculty of Medicine, Toyama University
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- Miyawaki Toshio
- Department of Pediatrics, Faculty of Medicine, Toyama University
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- Miura Osamu
- Department of Hematology, Tokyo Madical and Dental University
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抄録
A patient genetically diagnosed with X-linked agammaglobulinemia repeatedly developed bacteremia due to Campylobacter coli (C. coli) for one year and seven months in spite of immunoglobulin replacement therapy. Throughout the clinical course, C. coli with identical genetic patterns was repeatedly isolated from both blood and stool cultures, thus indicating that the patient had latent intestinal infection. The bacteremia was always accompanied by reactive arthritis. Since the immunoglobulin level was extremely low with severe B cell deficiency, the reactive arthritis must have been induced in a humoral immunity-independent manner. Adding oral minocycline following intravenous meropenem was very effective; the stool cultures became negative and the patient has been well for more than one year without relapse of bacteremia.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 46 (9), 605-609, 2007
一般社団法人 日本内科学会