Negative Correlation of Anti-U1RNP Antibody Titers and the Amount of Salivary Secretion with Age Correction

• Takada Kunio

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Suzuki Kimihiro

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Matsumoto Mitsuyo

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Okada Makoto

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Nakanishi Takashi

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Horikoshi Hideyuki

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Higuchi Tomoaki

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

• Ohsuzu Fumitaka

  Department of Internal Medicine, Division of Rheumatology, National Defense Medical College

抄録

Objective The aim of this study was to reveal whether or not the presence of anti-U1RNP antibodies is associated with a low amount of salivary secretion (ASS).<br> Subjects and Methods Twenty females (mean age 49±12 years) who had anti-U1RNP but not ACA, anti-Ro, or anti-La antibodies (anti-U1RNP-positive group), and 65 control females (mean age 50±12 years) were included in this study. The saxon test was performed to measure the ASS.<br> Results After a correction for age by ANCOVA, ASS in the anti-U1RNP-positive group was significantly lower than ASS in the control group (p <0.001). In the control group, ASS was not significantly decreased with advanced age (r=-0.140, p=0.211). In the anti-U1RNP-positive group, ASS was decreased with age, without a significant difference (r=-0.379, p=0.100). In the next analysis, we introduced 'ASS with age correction', assuming that all subjects in the anti-U1RNP-positive group were 49 years of age. A negative correlation between the titers of anti-U1RNP antibodies and the ASS with the age correction in the anti-U1RNP-positive group was noted (r=-0.520, p=0.019). The log of the antinuclear antibodies titers, or titers of rheumatoid factor was significantly correlated with the titers of anti-U1RNP antibodies, respectively (r=0.466, p=0.038 and r=0.595, p=0.006; respectively). The pathological findings of minor salivary gland biopsy in 2 subjects were compatible with Sjögren's syndrome; one subject showed moderate lymphocytic infiltration.<br> Conclusion The presence of anti-U1RNP antibodies is associated with reduced ASS.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 47 (5), 385-390, 2008

  一般社団法人 日本内科学会

キーワード

• anti-U1RNP antibodies
• saliva
• sicca
• the Saxon test

詳細情報

• CRID: 1390282679848593920
• NII論文ID: 130000079697
• DOI: 10.2169/internalmedicine.47.0426
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/47/5/47_5_385/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008245503
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可