Nutritional and Prognostic Significance of Sick Euthyroid Syndrome in Non-small Cell Lung Cancer Patients

• EkremCengiz Seyhan

  Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Cetinkaya Erdogan

  Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Altin Sedat

  Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Gunluoglu Zeki

  Department of Thoracic Surgery, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Demir Adalet

  Department of Thoracic Surgery, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Gunluoglu Gulsah

  Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

• Epozturk Kursat

  Department of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital

抄録

Objectives Our study aimed to determine the frequency of sick euthyroid syndrome (SES) among patients diagnosed as non-small cell lung cancer (NSCLC) and its association with the stage of the disease, Karnofsky index (KI), and nutritional parameters.<br> Methods We enrolled 80 consecutive patients with newly diagnosed NSCLC. Cases with NSCLC were staged by using the TNM system. The cases were examined for thyroid function tests, KI and nutritional evaluation before treatment. Moreover, cases were investigated for their overall survival ratio.<br> Results Out of 80 patients, SES was identified in 28 (35%). SES was more frequent among stage III (26%) and stage IV (62%) cases. The body mass index (BMI), KI and serum albumin level were found to be significantly low in cases with SES when compared to cases without SES. SES was found to be negatively correlated with BMI, KI and serum albumin level, and it was positively correlated with disease stage and weight loss. Additionally, the presence of SES was found as a prognostic factor at survival analysis (p=0.0002).<br> Conclusion SES was frequently seen in cases with NSCLC. SES can be used as a predictor of poor prognosis in NSCLC patients.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 47 (4), 211-216, 2008

  一般社団法人 日本内科学会

キーワード

• sick euthyroid syndrome
• NSCLC
• nutritional parameters

詳細情報

• CRID: 1390001204871027712
• NII論文ID: 130000079725
• DOI: 10.2169/internalmedicine.47.0423
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/47/4/47_4_211/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008244258
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可