Fatal Acute Tumor Lysis Syndrome following Intrathecal Chemotherapy for Acute Lymphoblastic Leukemia with Meningeal Involvement

DOI Web Site 参考文献5件
  • Konuma Takaaki
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Ooi Jun
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Takahashi Satoshi
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Tomonari Akira
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Tsukada Nobuhiro
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Kato Seiko
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Sato Aki
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Monma Fumihiko
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Uchimaru Kaoru
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo
  • Tojo Arinobu
    Department of Hematology/Oncology, Institute of Medical Science, University of Tokyo

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抄録

Acute tumor lysis syndrome (ATLS) is a well-recognized complication of systemic chemotherapy for rapidly proliferating neoplasms. ATLS has rarely occurred after intrathecal chemotherapy for the treatment of leukemia with meningeal involvement. Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation. This case indicates that intrathecal chemotherapy alone may be sufficient to induce ATLS. Close monitoring and prevention of ATLS are also warranted following intrathecal chemotherapy alone.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 47 (22), 1987-1988, 2008

    一般社団法人 日本内科学会

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