Human Herpes Virus 8-negative Primary Effusion Lymphoma (PEL) in a Patient after Repeated Chylous Ascites and Chylothorax

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  • NONAMI Atsushi
    Department of Hematology, National Kyushu Medical Center Clinical Research, National Kyushu Medical Center
  • YOKOYAMA Toshihiro
    Department of Hematology, National Kyushu Medical Center Clinical Research, National Kyushu Medical Center
  • TAKESHITA Morishige
    Pathology, National Kyushu Medical Center Clinical Research, National Kyushu Medical Center
  • OHSHIMA Koichi
    Department of Pathology, School of Medicine, Fukuoka University
  • KUBOTA Akira
    Department of Hematology, National Kyushu Medical Center Clinical Research, National Kyushu Medical Center
  • OKAMURA Seiichi
    Department of Hematology, National Kyushu Medical Center Clinical Research, National Kyushu Medical Center

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抄録

We describe a case of malignant lymphoma which presented in the body cavities without identifiable tumor masses. Malignant lymphoma cells showed strong atypia with prominent nuclei and basophilic cytoplasm containing vacuoles. The chromosomes showed diploidy and complex abnormalities including translocations and deletions. We diagnosed this patient with primary effusion lymphoma (PEL), even though she tested negative for human herpes virus-8 (HHV-8) which has been suggested to be causally related to PEL. Interestingly, the patient also showed complicated protein-losing enteropathy, and PEL occurred after repeated chylous ascites and chylothorax. The possible pathogenesis of this rare disease is discussed here.

収録刊行物

  • Internal Medicine

    Internal Medicine 43 (3), 236-242, 2004

    一般社団法人 日本内科学会

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