Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure
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- SAIJO Mieko
- Second Department of Internal Medicine, Gifu University School of Medicine
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- TAKEMURA Genzou
- Second Department of Internal Medicine, Gifu University School of Medicine
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- KODA Masahiko
- Second Department of Internal Medicine, Gifu University School of Medicine
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- OKADA Hideshi
- Second Department of Internal Medicine, Gifu University School of Medicine
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- MIYATA Shusaku
- Second Department of Internal Medicine, Gifu University School of Medicine
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- OHNO Yasushi
- Second Department of Internal Medicine, Gifu University School of Medicine
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- KAWASAKI Masanori
- Second Department of Internal Medicine, Gifu University School of Medicine
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- TSUCHIYA Kunihiko
- Second Department of Internal Medicine, Gifu University School of Medicine
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- NISHIGAKI Kazuhiko
- Second Department of Internal Medicine, Gifu University School of Medicine
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- MINATOGUCHI Shinya
- Second Department of Internal Medicine, Gifu University School of Medicine
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- GOTO Koshi
- Second Department of Internal Medicine, Gifu University School of Medicine
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- FUJIWARA Hisayoshi
- Second Department of Internal Medicine, Gifu University School of Medicine
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A 75-year-old man without overt heart failure showed an abnormally high level of brain natriuretic peptide (BNP) in plasma: 600 pg/ml. The left ventricular endomyocardial biopsy revealed prominent vacuolar degeneration in the myocytes, most of which were positive for PAS stain and BNP immunoreaction. Ultrastructurally, degenerative changes of myocytes were marked, such as deposits of glycogen and lipofuscin granules in the cytoplasm, but the most prominent finding was giant vacuoles containing degraded mitochondria, glycogen granules, myofibrils, and myelin-like structures (autophagosomes). This case may belong to one of the unclassified cardiomyopathies characterized by prominent autophagic vacuoles.
収録刊行物
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- Internal Medicine
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Internal Medicine 43 (8), 700-703, 2004
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679844893952
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- NII論文ID
- 130000084885
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- NII書誌ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD2crgtVGktg%3D%3D
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- ISSN
- 13497235
- 09182918
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- HANDLE
- 20.500.12099/31794
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- NDL書誌ID
- 7059612
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- PubMed
- 15468969
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可