-
- Aoki Yosuke
- Department of Food and Health Science, Faculty of Human Life Science, Jissen Women's University
この論文をさがす
抄録
Addition of azurocidin, a protein in granulocytes similar to serine proteases but has no protease activity because of replacement of the active serine residue by glycine, to the incubation mixture containing medullasin induced elastinolytic activity of medullasin. Both medullasin and human leukocyte elastase were already shown to have negligible elastinolytic activity (Aoki, Y. et al. J. Biochem. 114, 122, 1993). Elastinolytic activity of medullasin was induced dose-dependently by the addition of azurocidin. Medullasin activity determined by using apo-ornithine transaminase or casein as substrates or that by N-methoxy-succinyl-(Ala)2-Pro-Val-p-nitroanilide as substrate remained unchanged when azurocidin was added to the tube containing medullasin. Therefore, azurocidin is considered to cause an appearance of elastinolytic activity of medullasin without affecting the protease activity of it.<br><br>(Edited by Masanori OTSUKA, M.J.A.)
収録刊行物
-
- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
-
Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 82 (7), 251-256, 2006
日本学士院
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679122710656
-
- NII論文ID
- 130000093845
-
- NII書誌ID
- AA00785485
-
- ISSN
- 13492896
- 03862208
-
- NDL書誌ID
- 8514349
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可