GnRH Agonist Acts as Ovarian Protection in Chemotherapy Induced Gonadotoxicity: An Experiment Using a Rat Model

• MATSUO GO

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• USHIJIMA KIMIO

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• SHINAGAWA ATSUHIKO

  Shinagawa Hospital

• TAKAHASHI SYUN-ICHI

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• FUJIYOSHI NAOKI

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• TAKEMOTO SYUJI

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• TERADA ATSUMU

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• FUKUI AKIMASA

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

• KAMURA TOSHIHARU

  Department of Obstetrics and Gynecology, Kurume University School of Medicine

抄録

To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 μg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest section of the ovary on the 5th and 10th day after administration. Leuplin led the ovary to a resting phase in which primordial follicle occupied 80% of all follicles in only 5 days after administration. The serum E2 level was also down by the 5th day and maintained a low level to the 10th day. In co-treatment with GnRHa and CDDP rats, the primordial follicle occupied 90% of all follicles and the total number of follicles was higher than in CDDP alone rats. This rat model verified that GnRHa co-treatment well minimized CDDP induced gonadotoxocity by desensitization of the ovary. These results were promising for the clinical application introducing GnRHa co-treatment as ovarian protection in cancer chemotherapy in young women.

収録刊行物

• Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ

  Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ 54 (1/2), 25-29, 2007

  久留米大学医学部 The Kurume Medical Journal 編集部

キーワード

• GnRH agonist
• chemotherapy related amenorrhea
• ovarian protection
• apoptosis

詳細情報

• CRID: 1390282681320525696
• NII論文ID: 130000097806
• DOI: 10.2739/kurumemedj.54.25
• ISSN: 18812090
• ISSN: 00235679
• Web Site: https://search.jamas.or.jp/link/ui/2008230814
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可