Effects of Yokukansan, a Traditional Japanese Medicine, on Memory Disturbance and Behavioral and Psychological Symptoms of Dementia in Thiamine-Deficient Rats

• Ikarashi Yasushi

  Tsumura Research Laboratories, Tsumura & Co.

• Iizuka Seiichi

  Tsumura Research Laboratories, Tsumura & Co.

• Imamura Sachiko

  Tsumura Research Laboratories, Tsumura & Co.

• Yamaguchi Takuji

  Tsumura Research Laboratories, Tsumura & Co.

• Sekiguchi Kyoji

  Tsumura Research Laboratories, Tsumura & Co.

• Kanno Hitomi

  Tsumura Research Laboratories, Tsumura & Co.

• Kawakami Zenji

  Tsumura Research Laboratories, Tsumura & Co.

• Yuzurihara Mitsutoshi

  Tsumura Research Laboratories, Tsumura & Co.

• Kase Yoshio

  Tsumura Research Laboratories, Tsumura & Co.

• Takeda Shuichi

  Tsumura Research Laboratories, Tsumura & Co.

抄録

Effects of yokukansan (TJ-54) on memory disturbance and behavioral and psychological symptoms of dementia (BPSD) were investigated in thiamine-deficient (TD) rats which were produced by feeding a TD diet for 37 d. Daily oral administration of TJ-54 (0.5, 1.0 g/kg) ameliorated the memory disturbance, anxiety-like behavior, the increase in aggressive behaviors, the decrease in social behaviors, and several neurological symptoms including opisthotonus observed in TD rats, in a dose-dependent manner. In addition, histopathological examinations showed that TJ-54 inhibited the degeneration of neuronal and astroglial cells in the brain stem, hippocampus and cortex in TD rats. Microdialysis experiments showed that TJ-54 inhibited extracellular glutamate rise in the ventral posterior medial thalamus in TD rats. These results suggest that TJ-54 possesses the preventive or progress inhibitive effect against the development of memory disturbance and BPSD-like behaviors induced by the degeneration of neuronal and astroglial cells resulting from TD. TJ-54 may inhibit glutamate-mediated excitotoxicity as one of mechanisms.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 32 (10), 1701-1709, 2009

  公益社団法人 日本薬学会

キーワード

• yokukansan
• thiamine
• memory
• aggression
• anxiety
• astrocyte

詳細情報

• CRID: 1390282679601690112
• NII論文ID: 130000116930
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.32.1701
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10375804
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10375804
• Web Site: http://www.jstage.jst.go.jp/article/bpb/32/10/32_10_1701/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010089378
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可