Alterations in Pharmacological Action of the Right Ventricle of Monocrotaline-Induced Pulmonary Hypertensive Rats

• Daicho Takuya

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Yagi Tatsuya

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Takano Saori

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Marunouchi Tetsuro

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Abe Yohei

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Ohara Meiko

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Takeo Satoshi

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

• Tanonaka Kouichi

  Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences

抄録

The present study was undertaken to elucidate pathophysiological and pharmacological alterations in the right ventricle in monocrotaline-administered (MCT) rats. Examination of tissue weights of the MCT and age-matched control (CON) rats indicated the right ventricular (RV) hypertrophy until 8 weeks after a single subcutaneous administration of 60 mg/kg MCT. Apparent fibrosis in the right ventricle of the MCT rat at the 6th week (6w-MCT) was observed. Echocardiographic measurement of the cardiac and hemodynamic parameters of the MCT rat showed decreases in cardiac output and stroke volume indices at the 6th and 8th weeks. The RV Tei index, which increase represents aggravation of RV function, was augmented at the 4th to 8th week. The results suggest the genesis of cardiac and RV failure until 6 weeks after MCT administration. Injection of dobutamine (300 ng) or colforsin daropate (1 μg) into the perfused right ventricle isolated from CON rat at the 6th week resulted in a marked increase in cardiac double product, whereas injection of either agent into the right ventricle from the 6w-MCT rat elicited a small increase in the double product, followed by a sustained decrease in the developed tension. Infusion of acetylcholine (1 μg) into the RV muscle of the 6w-MCT rat resulted in prolongation of the periods for cardiac arrest and for bradycardia of the right ventricle. The results suggest that MCT administration causes the RV hypertrophy and eventually leads to the RV failure, accompanied by abnormal inotropic and chronotropic actions of the RV muscle.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 32 (8), 1378-1384, 2009

  公益社団法人 日本薬学会

キーワード

• right ventricular failure
• echocardiography
• pharmacological alteration
• monocrotaline

詳細情報

• CRID: 1390001204627926144
• NII論文ID: 130000117251
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.32.1378
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10289981
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10289981
• Web Site: http://www.jstage.jst.go.jp/article/bpb/32/8/32_8_1378/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010000896
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可