Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution
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- Osamura Robert Y.
- Department of Pathology, Tokai University School of Medicine
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- Egashira Noboru
- Department of Pathology, Tokai University School of Medicine
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- Kajiya Hanako
- Department of Pathology, Tokai University School of Medicine
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- Takei Mao
- Department of Pathology, Tokai University School of Medicine Department of Neurosurgery, Nippon Medical School
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- Tobita Maya
- Department of Pathology, Tokai University School of Medicine Division of Diabetes, Metabolism and Endocrinology, Jikei University School of Medicine
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- Miyakoshi Takashi
- Department of Pathology, Tokai University School of Medicine
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- Inomoto Chie
- Department of Pathology, Tokai University School of Medicine
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- Takekoshi Susumu
- Department of Pathology, Tokai University School of Medicine
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- Teramoto Akira
- Department of Neurosurgery, Nippon Medical School
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抄録
Growth hormone (GH)-producing adenomas (GHomas) are one of the most frequently-occurring pituitary adenomas. Differentiation of hormone-producing cells in the pituitary gland is regulated by transcription factors and co-factors. The transcription factors include Pit-1, Prop-1, NeuroD1, Tpit, GATA-2, SF-1. Aberrant expression of transcription factors such as Pit-1 results in translineage expression of GH in adrenocorticotropic hormone-producing adenomas (ACTHomas). This situation has been substantiated by GFP-Pit-1 transfection expression in the AtT20 cell line. Experimentally, GHomas have been induced in GH-releasing hormone (GHRH) or Prop-1 transgenic animals. Immunohistochemical detection of somatostatin receptor (SSTR2a) has recently emphasized their role in the response of GHomas to somatostatin analogue therapy. In this review, the advances in technology and their contribution to cell biology and medical practice are discussed.<br>
収録刊行物
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- Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ
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Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 42 (4), 95-104, 2009
日本組織細胞化学会