Relationships between Quantitative Electroencephalographic Alterations and the Severity of Hepatitis C Based on Liver Biopsy in Interferon-.ALPHA. Treated Patients

• Kamei Satoshi

  Division of Neurology, Department of Medicine, Nihon University Itabashi Hospital

• Morita Akihiko

  Division of Neurology, Department of Medicine, Nihon University Itabashi Hospital

• Tanaka Naohide

  Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University Itabashi Hospital

• Matsuura Masato

  Department of Neuropsychiatry, Nihon University Itabashi Hospital

• Moriyama Mitsuhiko

  Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University Itabashi Hospital

• Kojima Takuya

  Department of Neuropsychiatry, Nihon University Itabashi Hospital

• Arakawa Yasuyuki

  Department of Neuropsychiatry, Nihon University Itabashi Hospital

• Matsukawa Yoshihiro

  Division of Hematology and Rheumatology, Department of Medicine, Nihon University Itabashi Hospital

• Mizutani Tomohiko

  Division of Neurology, Department of Medicine, Nihon University Itabashi Hospital

• Sakai Teiichiro

  Department of Neuropsychiatry, Nihon University Itabashi Hospital

• Oga Kentaro

  Department of Neuropsychiatry, Nihon University Surugadai Hospital

• Ohkubo Hitoshi

  Department of Internal Medicine, Nihon University Surugadai Hospital

• Matsumura Hiroshi

  Department of Internal Medicine, Itabashi Medical Association Hospital

• Hirayanagi Kaname

  Department of Hygiene and Public Health, Nihon University of Physical Education

抄録

Objective We have observed alterations of quantitative (q)-EEG findings occurring in interferon (IFN)-α treated chronic hepatitis C (CH-C) patients, and found patient's age to be one factor influencing such EEG alterations. In the present study we evaluated the correlation between q-EEG alterations during IFN-α treatment and the severity of hepatitis based on liver biopsies.<br> Methods A total of 102 CH-C patients underwent blind, prospective and serial q-EEG examinations. The IFN-α was administered under the same therapeutic regimen to all patients. Serial EEGs were obtained before, at 2 and 4 weeks, and at 2-3 days after the conclusion of treatment. The absolute powers of each frequency band in different periods were determined by q-EEG. Staging (of fibrosis) and grading (of inflammatory cell infiltration) were scaled according to Desmet's classification. We evaluated the relationship between q-EEG and scales of staging or grading.<br> Results Age distributions did not differ significantly among stages or grades. As the stage or grade increased, the alterations of EEG during IFN-α treatment became more pronounced, and significant (repeated-measures analysis of variances; both, p<0.0001).<br> Conclusion Alterations of the EEG occurring during IFN-α treatment became pronounced with more severe pathological findings for CH-C. Alterations in the EEGs during IFN-α treatment should be carefully monitored in CH-C patients with severe pathological findings.<br>

収録刊行物

• Internal Medicine

  Internal Medicine 48 (12), 975-980, 2009

  一般社団法人 日本内科学会

キーワード

• interferon-α
• quantitative-EEG
• chronic hepatitis C
• staging
• grading

詳細情報

• CRID: 1390001204871469568
• NII論文ID: 130000121892
• DOI: 10.2169/internalmedicine.48.1902
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/48/12/48_12_975/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010041235
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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