The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation

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  • Fujimoto Masumi
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
  • Ichikawa Tatsuki
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
  • Nakao Kazuhiko
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
  • Miyaaki Hisamitsu
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
  • Shibata Hidetaka
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
  • Eguchi Susumu
    Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
  • Takatsuki Mitsuhisa
    Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
  • Nagaoka Shinya
    Clinical Research Center, National Nagasaki Medical Center
  • Yatsuhashi Hiroshi
    Clinical Research Center, National Nagasaki Medical Center
  • Kanematsu Takashi
    Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University
  • Eguchi Katsumi
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University

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Abstract

Purpose Recently, a new enzyme immunoassay for the detection of hepatitis B virus (HBV) core-related antigen (HBcrAg) has been reported. In this study, we proposed to account for feasibility of HBcrAg assay, and discuss the dynamics of HBV seen in patients following HBV-related living donor liver transplantation (LDLT). <br> Methods and results This study involved 12 patients; 11 patients had positive serum HBcrAg, and 6 patients had negative HBV-DNA. In the post-operation period, all cases were negative for HBV-DNA and HBsAg in sera under prophylaxis therapy. At post-operation, 5 of the 12 had positive serum HBcrAg, and at stable state, 6 had positive serum HBcrAg postoperatively. The mean levels of HBcrAg following LDLT were significantly lower than those seen in the preoperative-operation stage. <br> Conclusion This enzyme immunoassay is a readily utilizable marker of HBV replication in the post transplantation stage. Furthermore, the evaluation of HBV activity by HBcrAg assay must be studied to determine the appropriate prophylaxis for controlling replication of HBV following LDLT.<br>

Journal

  • Internal Medicine

    Internal Medicine 48 (18), 1577-1583, 2009

    The Japanese Society of Internal Medicine

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