Pathology: Propagation of swine hemagglutinating encephalomyelitis virus and pseudorabies virus in dorsal root ganglia cells
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- HARA Yoko
- Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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- HASEBE Rie
- Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University
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- SUNDEN Yuji
- Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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- OCHIAI Kenji
- Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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- HONDA Eiichi
- Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology
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- SAKODA Yoshihiro
- Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
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- UMEMURA Takashi
- Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
書誌事項
- タイトル別名
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- Propagation of Swine Hemagglutinating Encephalomyelitis Virus and Pseudorabies Virus in Dorsal Root Ganglia Cells
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抄録
Swine hemagglutinating encephalomyelitis virus (HEV) causes encephalomyelitis or vomiting and wasting disease in suckling piglets. Neurotoropism of the virus has been demonstrated in previous in vivo studies. In the present study, we investigated the infectivity and propagation of HEV in comparison with those of pseudorabies virus (PRV), another neurotropic virus, using dorsal root ganglia cells of newborn mice containing nerve cells and non-neuronal cells. HEV infected nerve cells but did not infect non-neuronal cells, whereas PRV infected both cell types. By using cytoskeletal inhibitors, it was suggested that propagation of HEV and PRV within and among nerve cells depended on microtubules and intermediate filaments of nerve cells, indicating that the viruses may be transported between the cell body and axonal terminals of neurons by fast axonal flow.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 71 (5), 595-601, 2009
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206430813440
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- NII論文ID
- 130000134370
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10314334
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可