Virology: Bovine viral diarrhea virus 2 infection activates the unfolded protein response in MDBK cells, leading to apoptosis
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- MAEDA Kouji
- Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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- FUJIHARA Masatoshi
- Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
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- HARASAWA Ryô
- Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Bovine viral diarrhea virus 2 Infection Activates the Unfolded Protein Response in MDBK Cells, Leading to Apoptosis
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抄録
Bovine viral diarrhea virus 2 (BVDV-2) strains are divided into cytopathic and non-cytopathic biotypes based on the ablity to induce cytopathic effects in cultured cells. The mechanism of cytopathogenicity of BVDV-2 is not well understood. We examined cytopathogenesis in MDBK cells resulting from BVDV-2 infections by microscopic examinations and microarray analysis. We found that BVDV-2 activates endoplasmic reticulum (ER) stress signaling pathways that contribute to apoptosis of infected cells. We also monitored the expression of ER stress marker gene by RT-PCR during BVDV-2 infection and demonstrated that infection of MDBK cells with a cytopathic strain of BVDV-2 induces glucose-regulated protein 78 expression. Infection with BVDV-2 also induces DNA-damage-inducible transcript 3 expression and downregulates the lectin-galactoside-binding soluble 1 level. These results show that cytopathic strains of BVDV-2 induce an ER stress response resulting in apoptosis.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 71 (6), 801-805, 2009
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428432768
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- NII論文ID
- 130000134407
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10349853
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可