Pharmacokinetics of Penciclovir after Oral Administration of its Prodrug Famciclovir to Horses
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- TSUJIMURA Koji
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- YAMADA Masayuki
- Laboratory of Racing Chemistry
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- NAGATA Shun-ichi
- Laboratory of Racing Chemistry
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- YAMANAKA Takashi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- NEMOTO Manabu
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- KONDO Takashi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- KUROSAWA Masahiko
- Laboratory of Racing Chemistry
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- MATSUMURA Tomio
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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We investigated the pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses. Following an oral dose of famciclovir at 20 mg/kg, maximum plasma concentrations of penciclovir occurred between 0.75 and 1.5 hr (mean 0.94 ± 0.38 hr) after dosing and were in the range 2.22 to 3.56 μg/ml (mean 2.87 ± 0.61 μg/ml). The concentrations of penciclovir declined in a biphasic manner after the peak concentration was attained. The mean half-life of the rapid elimination phase was 1.73 ± 0.34 hr whereas that of the slow elimination phase was 34.34 ± 13.93 hr. These pharmacokinetic profiles observed were similar to those of another antiherpesvirus drug, acyclovir, previously reported in horses following oral dosing of its prodrug valacyclovir.<br>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 72 (3), 357-361, 2010
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681407541120
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- NII論文ID
- 130000134548
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- ISSN
- 13477439
- 09167250
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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