Effect of Chondroitinase on Dermatan Sulfate-Facilitated Arginine Amidase Released from Rabbit Ear Artery

• Ishii-Nozawa Reiko

  Department of Clinical Pharmacology, Meiji Pharmaceutical University

• Naito Tatsuya

  Department of Clinical Pharmacology, Meiji Pharmaceutical University

• Mita Mitsuo

  Department of Pharmacodynamics, Meiji Pharmaceutical University

• Miyazaki Kyosuke

  Seikagaku Kogyo Co.

• Matsuda Yoshifumi

  Department of Functional Bioanalysis, Meiji Pharmaceutical University

• Takeuchi Koichi

  Department of Clinical Pharmacology, Meiji Pharmaceutical University

抄録

We examined the effects of chondroitinases on the release of dermatan sulfate (DS)-induced arginine amidase (AA) from rabbit ear artery. DS-induced AA release was significantly decreased by treatment with chondroitinase ABC (ABCase) in the rabbit ear artery. On the other hand, Chondroitinase ACII (ACIIase) enhanced spontaneous and DS-induced AA release. Heat-inactivated ABCase and ACIIase did not affect spontaneous and DS-induced AA release. Furthermore, ABCase, but not ACIIase and heat-inactivated chondroitinases, degraded DS. These results indicate that the facilitatory effect of DS-induced AA release from the rabbit ear artery is affected by the molecular size of DS.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33 (1), 150-152, 2010

  公益社団法人 日本薬学会

キーワード

• arginine amidase
• dermatan sulfate
• rabbit ear artery
• chondroitinase ABC
• chondroitinase ACII

詳細情報

• CRID: 1390001204624818176
• NII論文ID: 130000140211
• NII論文ID: 40016900233
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.33.150
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10497697
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10497697
• Web Site: http://www.jstage.jst.go.jp/article/bpb/33/1/33_1_150/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010153095
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可