Pharmacology: Preventive effects of Chinese herb Chai-hu-gui-zhi-tang extract on water immersion restraint stress-induced acute gastric ulceration in rats

• CHEN Chi-Yang

  Graduate Institute of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University

• KUO Tsung-Li

  Department of Forensic Medicine, College of Medicine, National Taiwan University

• SHEU Shi-Yuan

  School of Chinese Medicine, China Medical University Department of Acupuncture, E-DA Hospital / I-Shou University

• KUO Tzong-Fu

  Graduate Institute of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University

書誌事項

タイトル別名

• Preventive Effects of Chinese Herb Chai-Hu-Gui-Zhi-Tang Extract on Water Immersion Restraint Stress-Induced Acute Gastric Ulceration in Rats

抄録

It is well known that maintenance therapy using Chai-hu-gui-zhi-tang (CHGZT), a traditional Chinese medicine, has been proven to prevent the recurrence of peptic ulcers. However, little is known as to whether or not it has protective effects against acute gastric injury. In the present study, we investigated the preventive effects of pretreatment with CHGZT extract on the development of water immersion restraint stress-induced acute gastric ulceration in male Wistar rats. The CHGZT extract (50, 250, 500 mg/kg b.w., p.o.) was given to rats before they were exposed to 2 or 4 hr of water immersion restraint stress; they were then were sacrificed immediately after stress exposure. Gastric mucosal lesions were evaluated macroscopically, and the gastric mucosal and hepatic non-protein sulfhydryls (NP-SH) were measured simultaneously. The results indicate that exposure to water immersion restraint stress resulted in the development of acute gastric stress erosions. Pretreatment with CHGZT extract caused a significant reduction of stress lesions and an increase in the gastric mucosal NP-SH and hepatic NP-SH concentrations. We conclude that the anti-ulcer response and extensive antioxidant effect of Chai-hu-gui-zhi-tang may be valuable in prevention of experimental gastric mucosal lesions in rats because it possesses preventive and gastroprotective effects.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 72 (6), 679-685, 2010

  公益社団法人 日本獣医学会

キーワード

• antioxidant effect
• Chai-hu-gui-zhi-tang (CHGZT)
• gastric ulcer
• non-protein sulfhydryls
• water immersion restraint stress

詳細情報

• CRID: 1390282681405602560
• NII論文ID: 130000149859
• NII書誌ID: AA10796138
• DOI: 10.1292/jvms.09-0284
• ISSN: 13477439
• ISSN: 09167250
• NDL書誌ID: 10749994
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10749994
• Web Site: http://www.jstage.jst.go.jp/article/jvms/72/6/72_09-0284/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010284065
• 本文言語コード: en
• データソース種別:
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