加齢指標タンパク質SMP30/GNLノックアウトマウスを用いた抗老化研究

• 石神 昭人

  東邦大学薬学部生化学

書誌事項

タイトル別名

• Anti-aging Research Using SMP30/GNL Knockout Mice
• カレイシヒョウ タンパクシツ SMP30 GNL ノックアウトマウス オ モチイタ コウロウカ ケンキュウ

抄録

  Senescence Marker Protein-30 (SMP30) was originally identified as a novel protein in the rat liver, the expression of which decreases with aging. Recently, we identified SMP30 as the lactone-hydrolyzing enzyme gluconolactonases (GNL) of animal species. GNL was a key enzyme which involved in vitamin C biosynthesis, and the essential role of SMP30 in this synthetic process was verified by a nutritional study. SMP30 knockout mice developed symptoms of scurvy when fed a vitamin C-deficient diet, verifying the pivotal role of SMP30 in vitamin C biosynthesis. Moreover, SMP30 knockout mice were shorter in life span than the wild type when fed autoclaved mouse chow contained ∼55 mg/kg of vitamin C, which we now know contains too little vitamin C to maintain normal levels of vitamin C in tissues. These results demonstrate that vitamin C deficiency shortens longevity, that is, vitamin C deficiency accelerates aging.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 130 (1), 25-28, 2010-01-01

  公益社団法人 日本薬学会

キーワード

• aging
• ascorbic acid
• gluconolactonase
• vitamin C

詳細情報

• CRID: 1390282681104184064
• NII論文ID: 130000152006
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.130.25
• COI: 1:CAS:528:DC%2BC3cXosFKgsLw%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 10527339
• PubMed: 20046061
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10527339
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/130/1/130_1_25/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010180000
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可