Plasma Adiponectin Levels and Left Ventricular Remodeling in Hypertrophic Cardiomyopathy
-
- Kitaoka Hiroaki
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Kubo Toru
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Okawa Makoto
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Yamasaki Naohito
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Matsumura Yoshihisa
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Nishinaga Masanori
- Department of Medicine and Geriatrics, Kochi Medical School
-
- Doi Yoshinori L.
- Department of Medicine and Geriatrics, Kochi Medical School
この論文をさがす
抄録
Adiponectin, which is an adipose-derived protein with antiatherosclerogenic activities, has been reported to be elevated in patients with heart failure. However, there are no reports on the significance of adiponectin in patients with hypertrophic cardiomyopathy (HCM). The purpose of this study was to elucidate the clinical significance of plasma adiponectin levels in HCM patients.<br>Clinical characteristics, echocardiographic parameters, and levels of plasma B-type natriuretic peptide (BNP) and adiponectin were evaluated in 106 HCM patients. The plasma adiponectin levels were 10.8 ± 6.3 (range, 2.7-37.3) μg/mL. Plasma adiponectin levels were positively related to age and inversely related to body mass index (BMI). Among echocardiographic parameters, % fractional shortening (r = -0.20, P = 0.03) and maximum LV wall thickness (r = -0.23, P = 0.02) were inversely related to plasma adiponectin levels. A significant correlation between plasma adiponectin levels and BNP levels was also observed (r = 0.27, P = 0.005). In multivariate analysis, BMI, % fractional shortening, and plasma BNP levels were independent predictors of plasma adiponectin levels.<br>Plasma adiponectin levels are associated with impaired LV systolic function in HCM patients, but not with the LV outflow gradient. Together with BNP, adiponectin can be a useful biomarker for assessing disease severity in HCM patients.
収録刊行物
-
- International Heart Journal
-
International Heart Journal 51 (1), 51-55, 2010
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282680203804672
-
- NII論文ID
- 130000162396
-
- ISSN
- 13493299
- 13492365
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可