Possible Contribution of Ischemia of the Conus Branch to Induction or Augmentation of Brugada Type Electrocardiographic Changes in Patients With Coronary Artery Disease

  • Yamaki Masaru
    Department of Emergency Medicine, Asahikawa Medical College
  • Sato Nobuyuki
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Myojo Takuya
    Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
  • Nishiura Takeshi
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Nishimura Masato
    Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
  • Nakamura Hideki
    Department of Cardiovascular Medicine, Abashiri Kohsei General Hospital
  • Okada Motoi
    Department of Emergency Medicine, Asahikawa Medical College
  • Fujita Satoshi
    Department of Emergency Medicine, Asahikawa Medical College
  • Go Kazutomo
    Department of Emergency Medicine, Asahikawa Medical College
  • Sakamoto Naka
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Tanabe Yasuko
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Takeuchi Toshiharu
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Kawamura Yuichiro
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
  • Hasebe Naoyuki
    Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College

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Abstract

Recent evidence suggests an association between vasospastic angina and Brugada syndrome. Here we present two cases of coronary artery disease who presented with ECG abnormalities which might have been provoked or enhanced by ischemia of the conus branch of the right coronary artery. The 12-lead ECGs demonstrated normal sinus rhythm in these two cases. Interestingly, a saddle back or coved type ST segment elevation in leads V1-V3 was documented either in the percutaneous transluminal angioplasty procedure of the proximal right coronary artery or with an intracoronary acetylcholine (Ach) administration into the right coronary artery. These Brugada type ECG changes were restored to the baseline ECG waveform after improvement in the ischemia. In the second case, vasospasms of the conus branch of the right coronary artery were associated with a coved type ST segment elevation in leads V1 to V2. We discuss the possible interaction between ischemia caused by conus branch lesions and Brugada type electrocardiographic changes.

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