生体内微小環境による幹細胞の制御

  • 帯刀 益夫
    東北大学加齢医学研究所・分子発生研究分野

書誌事項

タイトル別名
  • Regulation of stem cells in microenvironment.

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抄録

In bone marrow, stromal cells may provide the microenvironment for self-renewal and differentiation of hematopoieticstem/progenitor cells through complex cell-cell interaction. To elucidate the regulatory mechanisms ofhematopoiesis by stromal cells, we established many stromal cell lines from various hematopoietic organs. Wethen reconstructed the in vitro hematopoietic microenvironment and succeeded to establish the stroma-dependenthematopoietic cell lines. This in vitro system may be useful to find regulatory factors involved in the hematopoietic microenvironment.

収録刊行物

  • 炎症・再生

    炎症・再生 23 (1), 18-22, 2003

    一般社団法人 日本炎症・再生医学会

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