Invariant V.ALPHA.14 Natural Killer T Cell Activation by Edible Mushroom Acidic Glycosphingolipids

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著者

    • Nakamura Kimihide
    • Health Care Administration Center, Obihiro University of Agriculture and Veterinary Medicine
    • Ohba Kiyoshi
    • Hokkaido Tokachi Area Regional Food Processing Technology Center
    • Ohnishi Masao
    • Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
    • Imai Kunitoshi
    • Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine
    • Igarashi Yasuyuki
    • Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • Kushi Yasunori
    • Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine

抄録

Invariant natural killer T (iNKT) cells regulate multi-immune response through Th1/Th2 cytokine release triggered by the recognition of CD1d-restricted glycosphingolipid antigens. Here we report that acidic glycosphingolipids (AGLs) of mushroom (Hypsizigus marmoreus and Pleurotus eryngii) presented by murine CD1d-transfected rat basophilic leukocytes induced interleukin-2 (IL-2) release from iNKT hybridoma cells. AGL-1, one of the AGLs, containing mannose at the non-reducing ends, induced CD1d-dependent IL-2 release. Al-though α-galactosylceramide (α-GalCer) presented by CD11c-positive cells induced both interferon-γ (IFN-γ) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. A single intravenous injection of AGLs into B6 mice induced only a little elevation of IL-4 in serum but repeated intravenous injection of AGLs induced prolonged retention of IL-4 in serum; therefore, these results suggested that edible mushroom AGLs might contribute to the retention of immunohomeostasis through the minimum induction of iNKT cell activation in vivo.

収録刊行物

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 33(4), 580-584, 2010

    公益社団法人 日本薬学会

各種コード

  • NII論文ID(NAID)
    130000248002
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    EN
  • ISSN
    0918-6158
  • NDL 記事登録ID
    10622582
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-V41
  • データ提供元
    NDL  J-STAGE 
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