Invariant Vα14 natural killer T cell activation by edible mushroom acidic glycosphingolipids

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  • Nozaki Hirofumi
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Itonori Saki
    Department of Chemistry, Faculty of Liberal Arts and Education, Shiga University
  • Sugita Mutsumi
    Department of Chemistry, Faculty of Liberal Arts and Education, Shiga University
  • Nakamura Kimihide
    Health Care Administration Center, Obihiro University of Agriculture and Veterinary Medicine
  • Ohba Kiyoshi
    Hokkaido Tokachi Area Regional Food Processing Technology Center
  • Ohnishi Masao
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
  • Imai Kunitoshi
    Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine
  • Igarashi Yasuyuki
    Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Suzuki Akemi
    Institute of Glycoscience, Tokai University
  • Kushi Yasunori
    Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine

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タイトル別名
  • Invariant V.ALPHA.14 Natural Killer T Cell Activation by Edible Mushroom Acidic Glycosphingolipids
  • Invariant V a 14 natural killer T cell activation by edible mushroom acidic glycosphingolipids

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抄録

Invariant natural killer T (iNKT) cells regulate multi-immune response through Th1/Th2 cytokine release triggered by the recognition of CD1d-restricted glycosphingolipid antigens. Here we report that acidic glycosphingolipids (AGLs) of mushroom (Hypsizigus marmoreus and Pleurotus eryngii) presented by murine CD1d-transfected rat basophilic leukocytes induced interleukin-2 (IL-2) release from iNKT hybridoma cells. AGL-1, one of the AGLs, containing mannose at the non-reducing ends, induced CD1d-dependent IL-2 release. Al-though α-galactosylceramide (α-GalCer) presented by CD11c-positive cells induced both interferon-γ (IFN-γ) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. A single intravenous injection of AGLs into B6 mice induced only a little elevation of IL-4 in serum but repeated intravenous injection of AGLs induced prolonged retention of IL-4 in serum; therefore, these results suggested that edible mushroom AGLs might contribute to the retention of immunohomeostasis through the minimum induction of iNKT cell activation in vivo.

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