Invariant V.ALPHA.14 Natural Killer T Cell Activation by Edible Mushroom Acidic Glycosphingolipids
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- Nozaki Hirofumi
- Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Itonori Saki
- Department of Chemistry, Faculty of Liberal Arts and Education, Shiga University
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- Sugita Mutsumi
- Department of Chemistry, Faculty of Liberal Arts and Education, Shiga University
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- Nakamura Kimihide
- Health Care Administration Center, Obihiro University of Agriculture and Veterinary Medicine
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- Ohba Kiyoshi
- Hokkaido Tokachi Area Regional Food Processing Technology Center
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- Ohnishi Masao
- Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- Imai Kunitoshi
- Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine
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- Igarashi Yasuyuki
- Laboratory of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
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- Suzuki Akemi
- Institute of Glycoscience, Tokai University
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- Kushi Yasunori
- Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
Bibliographic Information
- Other Title
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- Invariant Vα14 natural killer T cell activation by edible mushroom acidic glycosphingolipids
- Invariant V a 14 natural killer T cell activation by edible mushroom acidic glycosphingolipids
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Abstract
Invariant natural killer T (iNKT) cells regulate multi-immune response through Th1/Th2 cytokine release triggered by the recognition of CD1d-restricted glycosphingolipid antigens. Here we report that acidic glycosphingolipids (AGLs) of mushroom (Hypsizigus marmoreus and Pleurotus eryngii) presented by murine CD1d-transfected rat basophilic leukocytes induced interleukin-2 (IL-2) release from iNKT hybridoma cells. AGL-1, one of the AGLs, containing mannose at the non-reducing ends, induced CD1d-dependent IL-2 release. Al-though α-galactosylceramide (α-GalCer) presented by CD11c-positive cells induced both interferon-γ (IFN-γ) and IL-4 release, all of AGLs presented by CD11c-positive cells and AGL-1 presented by B cells induced IL-4 release from iNKT hybridoma cells. A single intravenous injection of AGLs into B6 mice induced only a little elevation of IL-4 in serum but repeated intravenous injection of AGLs induced prolonged retention of IL-4 in serum; therefore, these results suggested that edible mushroom AGLs might contribute to the retention of immunohomeostasis through the minimum induction of iNKT cell activation in vivo.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 33 (4), 580-584, 2010
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204628537600
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- NII Article ID
- 130000248002
- 120006390475
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 10622582
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed