Gambogenic Acid Inhibits Proliferation of A549 Cells through Apoptosis-Inducing and Cell Cycle Arresting

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  • Li Qinglin
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Cheng Hui
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Zhu Guoqi
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Yang Li
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Zhou An
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Wang Xiaoshan
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Fang Nianbai
    The first Affiliated Hospital, Anhui University of Traditional Chinese Medicine
  • Xia Lunzhu
    Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription (Hubei University of TCM), Ministry of Education
  • Su Jingjing
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Wang Mei
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Peng Daiying
    Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine
  • Xu Qi
    School of Education, Boston University

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抄録

Although anticancer effect of gambogic acid (GA) and its potential mechanisms were well documented in past decades, limited information is available on the anticancer effect of gambogenic acid (GNA), another major active component of Gamboge. Here we performed a study to determine whether GNA possesses anticancer effect and find its potential mechanisms. The results suggested that GNA significantly inhibited the proliferation of several tumor cell lines in vitro and in vivo. Treatment with GNA dose and time dependently induced A549 cells apoptosis, arrested the cells to G0/G1 phase in vitro and down-regulated the expression of cyclin D1 and cyclooxygenase (COX)-2 in mRNA level. In addition, anticancer effect was further demonstrated by applying xenografts in nude mice coupled with the characteristic of apoptosis in the GNA treated group. Taken together, these observations might suggest that GNA inhibits tumor cell proliferation via apoptosis-induction and cell cycle arrest.

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