Development of Liposomal Salbutamol Sulfate Dry Powder Inhaler Formulation

DOI Web Site Web Site 参考文献11件
  • Huang Wen-Hua
    School of Chinese Medicine, Hong Kong Baptist University
  • Yang Zhi-Jun
    School of Chinese Medicine, Hong Kong Baptist University
  • Wu Heng
    School of Chinese Medicine, Hong Kong Baptist University
  • Wong Yuen-Fan
    School of Chinese Medicine, Hong Kong Baptist University
  • Zhao Zhong-Zhen
    School of Chinese Medicine, Hong Kong Baptist University
  • Liu Liang
    School of Chinese Medicine, Hong Kong Baptist University

この論文をさがす

抄録

The purpose of our study was to develop a formulation of liposomal salbutamol sulfate (SBS) dry powder inhaler (DPI) for the treatment of asthma. Liposomes of high encapsulation efficiency (more than 80%) were prepared by a vesicular phospholipid gel (VPG) technique. SBS VPG liposomes were subjected to lyophilization using different kinds of cryoprotectants in various mass ratios. Coarse lactose (63—106 μm) in different mass ratios was used as a carrier. Magnesium stearate (0.5%) was added as a lubricator. The dry liposomal powders were then crushed by ball milling and sieved through a 400-mesh sieve to control the mean particle size at about 10 μm. The effects of different kinds of cryoprotectants and the amount of lactose carrier on the fine particle fraction (FPF) of SBS were investigated. The results showed that the developed formulation of liposomal dry powder inhaler was obtained using lactose as a cryoprotectant with a mass ratio of lyophilized powder to carrier lactose at 1 : 5; 0.5% magnesium stearate was used as a lubricator. The value of FPF for SBS was 41.51±2.22% for this formulation. Sustained release of SBS from the VPG liposomes was found in the in vitro release study. The study results offer the promising possibility of localized pulmonary liposomal SBS delivery in the anhydrous state.

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ